目的:探究C形臂X线定位下多次小直径钻孔联合体外冲击波疗法(extracorporeal shock wave therapy,ESWT)对早期股骨头坏死(osteonecrosis of the femoral head,ONFH)的临床疗效。方法:回顾分析2015年5月至2017年5月收治的早期ONFH患者106例,其中53例采用C形臂X线定位下多次小直径钻孔联合ESWT治疗作为观察组,男41例,女12例,年龄22~70(45.85±6.01)岁;另外53例仅采用ESWT治疗作为对照组,男34例,女19例,年龄20~68(45.12±5.83)岁。观察比较两组患者治疗前后髋关节屈曲范围、外展内收活动范围、ONFH面积比例,比较两组治疗前后改良Harris评分(modified Harris hip scores,mHHS),视觉模拟评分(visual analog scale,VAS)。采用Kaplan-Meier法绘制生存曲线,比较两组患者治疗后3年随访期间的股骨头生存率。结果:患者均无创口愈合不良及感染等并发症的发生。106例患者均获得随访,时间28~36(31.06±4.28)个月。观察组mHHS总分、髋关节屈曲范围、髋关节外展内收活动范围由治疗前(63.85±5.42)分、(23.79±2.21)°、(32.40±4.19)°分别增加至治疗后2年的(85.51±5.69)分、(34.65±2.73)°、(43.32±5.71)°(P<0.05);对照组分别由治疗前的(64.73±5.64)分、(23.82±2.18)°、(32.45±4.13)°增加至治疗后2年的(81.65±5.48)分、(32.79±2.87)°、(39.75±5.68)°(P<0.05)。观察组VAS、ONFH面积比例分别由治疗前的(5.76±1.41)分、(35.07±4.96)%降低至治疗后2年的(3.39±1.02)分、(22.04±3.23)%(P<0.05),对照组分别由治疗前的(5.73±1.45)分、(35.24±5.18)%降低至治疗后2年的(4.43±1.21)分、(28.32±3.76)%(P<0.05);治疗后两组间各项指标比较,差异均有统计学意义(P<0.05)。观察组患者治疗后3年的股骨头生存率明显高于对照组(P<0.05)。结论:C形臂X线定位下多次小直径钻孔联合ESWT治疗早期ONFH能够明显改善患者的临床症状,缓解疼痛,提高临床疗效。
Noninvasive low-intensity extracorporeal shockwave treatment(Li-ESWT)has been widely used to treat erection disorders.There is no clear information regarding either the selection of patients for the treatment or the treatment protocol.In this study,we aimed to investigate the efficacy of extracorporeal shockwave therapy in diabetic patients with severe erectile dysfunction(International Index of Erectile Function-5[IIEF-5]scores of 5 to 7).Sixty-three diabetes mellitus patients with erectile dysfunction having IIEF-5 scores of 5 to 7 and not showing a recovery of potency despite phosphodiesterase type 5 inhibitor therapy for the past 6 months were included in the study.The patients were evaluated based on their IIEF-5 scores and Erection Hardness Scale scores.The IIEF-5 score(mean±standard deviation[s.d.])increased from 5.29±1.67 to 5.56±1.85,with a difference of 0.27±0.18(P>0.05).The Erection Hardness Scale scores(mean±s.d.),on the other hand,increased from 1.46±0.50 to 1.48±0.50,with a difference of 0.02±0(P>0.05).In conclusion,the response to phosphodiesterase type 5 inhibitors did not change after extracorporeal shockwave treatment in diabetes mellitus patients with severe erectile dysfunction(IIEF-5 scores of 5 to 7).
